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A 20-Year Follow-up of First Episode Psychosis: Longitudinal Effects of Early Treatment Strategies and Relapse

NCT07616999 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 178

Last updated 2026-06-01

No results posted yet for this study

Summary

The study aims to address the following questions:

1. Do subgroups defined by early medication choices, relapse, and medication taken over 20 years differ in clinical, cognitive, and functional outcomes?
2. What are the long-term cognitive functioning trajectories, what factors predict these trajectories, and how do they relate to outcomes?
3. What might be the mechanisms behind medication discontinuation and poor long-term outcome, including the roles of multiple relapses and treatment resistance after first-episode psychosis?

Eligible patients will be invited to a one-time face-to-face interview. A trained research assistant will guide the participants through questions about their background, clinical symptoms, daily functioning, cognitive abilities, and psychological well-being.

Conditions

Sponsors & Collaborators

  • Research Grants Council, Hong Kong

    collaborator OTHER

  • The University of Hong Kong

    lead OTHER

Eligibility

Min Age
18 Years
Max Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-21
Primary Completion
2028-12-31
Completion
2028-12-31

Countries

  • China

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07616999 on ClinicalTrials.gov