Effect of Bupivacaine Liposome Injection on Muscle Strength After Total Knee Arthroplasty
NCT07616102 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 80
Last updated 2026-05-29
Summary
This study employs a randomized controlled trial to investigate whether bupivacaine liposome injection for adductor canal block can effectively improve lower limb muscle strength after total knee arthroplasty.
Conditions
- TKA
- Muscle Strength
Interventions
- PROCEDURE
-
a single-injection adductor canal block
An ultrasound-guided adductor canal block is performed via the conventional adductor canal approach. Under ultrasound guidance, 20 milliliters of 1.33% bupivacaine liposome is injected into the adductor canal.
- PROCEDURE
-
continuous femoral nerve block
An ultrasound-guided perineural sheath block of the femoral nerve is performed via the conventional femoral nerve approach. A femoral nerve catheter is then placed and connected to an analgesia pump containing 150 milliliters of 0.20% ropivacaine.
Sponsors & Collaborators
-
General Hospital of Ningxia Medical University
lead OTHER
Principal Investigators
-
Xinli Ni · General Hospital of Ningxia Medical University
Study Design
- Allocation
- RANDOMIZED
- Purpose
- TREATMENT
- Masking
- DOUBLE
- Model
- PARALLEL
Eligibility
- Min Age
- 60 Years
- Max Age
- 75 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-06-10
- Primary Completion
- 2026-10-30
- Completion
- 2026-11-03
Countries
- China
Study Locations
More Related Trials
-
Effectiveness of Adductor Canal Block Using Liposomal Bupivacaine
NCT04003506 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4
-
Liposomal Bupivacaine Versus Standard Bupivacaine in the Adductor Canal for Total Knee Arthroplasty
NCT03182933 ·Status: TERMINATED ·Phase: PHASE4
-
Liposomal Bupivacaine Versus Ropivacaine With Perineural Dexamethasone or Dexmedetomidine as Adjuncts for Adductor Canal Block Combined With IPACK Block in Total Knee Arthroplasty
NCT07509866 ·Status: RECRUITING ·Phase: NA
-
Liposomal Bupivacaine vs Adductor Canal Block in Total Knee Arthroplasty
NCT02863120 ·Status: COMPLETED ·Phase: PHASE4
-
Determination of the Optimal Volume of Liposomal Bupivacaine in Adductor Canal Block for Knee Joint Surgery
NCT06942689 ·Status: RECRUITING ·Phase: PHASE4
-
Trial of Liposomal Bupivacaine for TKA
NCT05635916 ·Status: COMPLETED ·Phase: PHASE4
-
Observation Study of the Pharmacokinetics of Adductor Canal Block
NCT04916392 ·Status: COMPLETED
-
Local Infiltration With Bupivacaine to Increase Quality of Post-operative Pain Control in Total Knee Replacement
NCT01364194 ·Status: COMPLETED ·Phase: PHASE4
-
Intraoperative Liposomal Bupivacaine Injection in Primary Total Knee Arthroplasty
NCT02341079 ·Status: WITHDRAWN ·Phase: PHASE2/PHASE3
-
Bupivacaine Liposome Suspension Versus a Concentrated Multi Drug Periarticular Injection
NCT02299349 ·Status: COMPLETED ·Phase: NA
-
Liposomal Bupivacaine Versus Standard of Care in Total Knee Surgery
NCT02219087 ·Status: COMPLETED ·Phase: NA
-
Liposomal Bupivacaine for Post Operative Pain After Knee Replacement Surgery
NCT02274870 ·Status: COMPLETED ·Phase: PHASE4
-
Adductor Canal Block in Total Knee Arthroplasty
NCT05715437 ·Status: UNKNOWN ·Phase: PHASE4
-
Efficacy of Pain Control in Different Bupivacaine Dose in Periarticular Injection in Bilateral Total Knee Arthroplasty
NCT03249662 ·Status: COMPLETED ·Phase: NA
-
Femoral Nerve Block With Liposome Bupivacaine for Postsurgical Analgesia Following Total Knee Arthroplasty
NCT01683071 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Plasma Concentrations of Bupivacaine After Peri-articular Injection in Total Knee Arthroplasty
NCT01636869 ·Status: COMPLETED ·Phase: PHASE4
-
Liposomal Bupivacaine in Total Knee Arthroplasty
NCT02426164 ·Status: WITHDRAWN ·Phase: PHASE4
-
Ultrasound-guided Adductor Canal Block for Total Knee Replacement
NCT02100579 ·Status: COMPLETED ·Phase: PHASE4
-
Liposomal Bupivacaine in Adductor Canal Blocks (ACB)
NCT04539730 ·Status: WITHDRAWN ·Phase: PHASE4
-
Comparison Between (GNB) Combined With (IPACK) Block Versus ACB in TKA
NCT06423339 ·Status: COMPLETED ·Phase: NA
-
Comparative Pain Control Between 0.2 or 0.3 Spinal Morphine and 0.25 or 0.5 % Bupivacaine for FNB After TKA
NCT00795223 ·Status: COMPLETED ·Phase: PHASE4
-
Adductor Canal Block Versus Periarticular Bupivicaine Injection in Total Knee Arthroplasty
NCT02777749 ·Status: COMPLETED ·Phase: PHASE4
-
Adductor Canal Blockade vs Femoral Nerve Blockade on Muscle Strength, Mobility and Pain After TKA
NCT01922596 ·Status: COMPLETED ·Phase: PHASE4
-
Clinical Observation of Bupivacaine Liposome for Lower Extremity Nerve Block
NCT07366905 ·Status: COMPLETED ·Phase: PHASE2
-
Liposomal Bupivacaine vs Perineural Adjuvants in Adductor Canalf and iPACK Blocks in Total Knee Arthroplasty
NCT07097493 ·Status: NOT_YET_RECRUITING ·Phase: PHASE4