Brain Connectivity Changes in Glioma Patients During Treatment

Summary

The goal of this observational study is to better understand how the brain changes during the treatment of glioma. In particular, the study looks at changes in important brain areas that are responsible for functions such as movement, language, or sensation, as well as the nerve fiber pathways that connect these areas.

The main question this study aims to answer is:

How do important brain areas and their connections adapt and reorganize over the course of glioma treatment?

Patients with glioma will undergo repeated brain imaging examinations as part of their regular medical care. These images will be analyzed over time to observe changes in brain activity and structure during different stages of therapy.

By studying these changes, researchers hope to gain new insights into the brain's ability to adapt (neuroplasticity) throughout the entire course of glioma treatment.

Conditions

• Glioma (Any Grade) in the Brain
• Gliomas, Malignant
• fMRI Research
• Neurocognitive Function

Sponsors & Collaborators

• Clinical Research Institute for Neurosciences, JKU Linz, Austria

  collaborator UNKNOWN

• Institute of Neuroradiology, Kepler University Hospital, Johannes Kepler University, Lin

  collaborator UNKNOWN

• Department of Neurosurgery, Kepler University Hospital, Johannes Kepler University Linz

  collaborator UNKNOWN

• Department of Radiation Oncology, Ordensklinikum Linz, Barmherzige Schwestern, Linz, Austria

  collaborator UNKNOWN

• Johannes Kepler University of Linz

  lead OTHER

Principal Investigators

• Raimund Kleiser, PD Dr. · Neuroimaging Sciences and Support Center ,Clinical Institute for Neurosciences, Institute of Neuroradiology, Kepler Unisversity Hospital Linz, Johannes Kepler University

• Andreas Gruber, Full Professor · Head of Clinical Institute for Neurosciences, Head of the Departmend of Neurosurgery, Kepler Unisversity Hospital Linz, Johannes Kepler University

• Hans Geinitz, Professor · Head of Department of Radiation Oncology, Clinical Institute for Neurosciences

• Michael Sonnberger, MD · Head of Institute of Neuroradiology, Kepler University Hospital Linz, Johannes Kepler University

Eligibility

Min Age

18 Years

Max Age

64 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-05-31

Primary Completion

2029-09-30

Completion

2029-12-31

Countries

• Austria

Study Locations