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Unilateral Ventilation on Cardiopulmonary Bypass During Cardiac Surgery

NCT07612709 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-05-29

No results posted yet for this study

Summary

This study investigates if single lung ventilation on cardiopulmonary bypass can mitigate postoperative lung water accumulation determined by lung ultrasound in the ventilated lung as compared to the non-ventilated lung in patients at high-risk for developing severe pulmonary complications after cardiac surgery.

Conditions

  • Lung Protective Ventilation
  • Cardiopulmonary Bypass
  • High-risk Cardiac Patients
  • Lung Ultrasound
  • Lung Water Assessment
  • Pulmonary Complications in Surgical Patients
  • Single-lung Ventilation
  • Chest X-ray for Clinical Evaluation
  • Electrical Impedance Tomography (EIT)
  • Lung Compliance
  • Oxygenation Indices
  • Biomarkers of Vascular Endothelial Injury

Interventions

PROCEDURE

Ventilated lung

This lung will be ventilated during cardiopulmonary bypass using volume-controlled ventilation with a tidal volume of 3 mL/kg ideal body weight, a PEEP of 5 cmH2O, a respiratory rate of 10/min, and a fraction of inspired oxygen of 30%.

PROCEDURE

Non-ventilated lung.

The contralateral lung will not be ventilated during cardiopulmonary bypass and will be allowed to collapse.

Sponsors & Collaborators

  • Medical University of Vienna

    lead OTHER

Principal Investigators

  • Martin Dworschak, MD, MBA · Medical University of Vienna

Study Design

Allocation
NA
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
65 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2028-12-31
Completion
2029-07-31

Countries

  • Austria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07612709 on ClinicalTrials.gov