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LTV (Low Tidal Volüme) Ventilation and Diaphragmatic Motion in CABG (Coronary Artery Bypass Grafting)

NCT07067684 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-03-18

No results posted yet for this study

Summary

The goal of this clinical trial is to evaluate whether low tidal volume (LTV) ventilation during cardiopulmonary bypass (CPB) surgery helps preserve diaphragmatic excursion in adult patients undergoing coronary artery bypass grafting (CABG). The study will also assess the relationship between LTV ventilation and postoperative pulmonary complications, such as atelectasis, pleural effusion, and pneumonia.

The main questions this trial aims to answer are:

Does LTV ventilation better preserve diaphragmatic motion compared to apnea during CPB?

Are postoperative pulmonary complications less frequent in patients receiving LTV?

Does LTV contribute to shorter extubation times and ICU stays?

Researchers will compare LTV ventilation with apnea (standard care) during CPB to assess its effects on diaphragmatic excursion, measured via ultrasound, and postoperative respiratory outcomes.

Participants will:

Undergo elective CABG surgery under general anesthesia

Be randomly assigned to receive either LTV ventilation or apnea during CPB

Have diaphragmatic excursion measured by ultrasound before surgery, before extubation, and 24 hours after surgery

Be monitored for postoperative pulmonary complications (atelectasis, effusion, pneumonia), extubation time, and ICU length of stay

Ultrasound will be used to measure diaphragmatic excursion (DE) in quiet and deep breathing. DE below 10 mm will be considered as diaphragmatic paralysis. Postoperative respiratory assessments will include blood gas analysis (PaO₂/FiO₂ ratio), clinical respiratory parameters, and imaging findings.

This is a prospective, single-center, assessor-blinded randomized controlled trial. Patients and outcome assessors will be blinded to group allocation. The study will be conducted at the Anesthesiology Clinic of Konya City Hospital and is expected to enroll 60 patients.

Conditions

  • Perioperative Respiratory Function
  • Diaphragmatic Dysfunction
  • Low Tidal Volume Ventilation

Interventions

OTHER

Low Tidal Volume Ventilation During CPB

Group Low: Patients in this group will receive low tidal volume mechanical ventilation during cardiopulmonary bypass (CPB). Ventilation settings will be: Tidal Volume: 3-4 mL/kg (ideal body weight) PEEP: 5-8 cmH₂O Respiratory Rate: adjusted to maintain normocapnia (PaCO₂ 35-45 mmHg)

Sponsors & Collaborators

  • Konya City Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
75 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-01
Primary Completion
2025-11-05
Completion
2025-11-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07067684 on ClinicalTrials.gov