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guideSEQ: Genomic Understanding, Impact, Decision & Ethics in Prenatal Sequencing

NCT07610590 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 1042

Last updated 2026-05-29

No results posted yet for this study

Summary

This study looks at whether genome sequencing should be used more routinely during pregnancy, even when ultrasounds look normal. Genome sequencing can examine nearly all of a baby's genes and may find genetic conditions that standard tests do not detect. Researchers will compare this test with current prenatal testing to see if it provides helpful information for families and doctors. The study will also explore how parents decide what kinds of genetic information they want to receive and how this information affects their experience during pregnancy. The goal is to understand whether genome sequencing can be used in a way that is helpful, responsible, and supportive for families in the future.

Conditions

  • Prenatal Genetic Diagnosis

Interventions

GENETIC

Genome Sequencing (GS)

Genome sequencing (GS) is a genetic test that involves reading the genome to identify genetic changes (also known as "genetic variants") that can cause differences in human development and disease.

Sponsors & Collaborators

  • Eunice Kennedy Shriver National Institute of Child Health and Human Development (NICHD)

    collaborator NIH

  • Columbia University

    lead OTHER

Principal Investigators

  • Ronald Wapner, MD · Columbia University Irving Medical Center (CUIMC)

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-29
Primary Completion
2029-07-31
Completion
2029-07-31

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07610590 on ClinicalTrials.gov