TRACP-5b for Diagnosis and Follow-up of Giant Cell Tumor of Bone

Summary

This prospective observational study will evaluate whether the blood biomarker TRACP-5b can help diagnose and monitor patients with giant cell tumor of bone (GCTB). GCTB is a rare but locally aggressive bone tumor that can return even after surgical treatment. Currently, patients require long-term follow-up based mainly on imaging examinations such as CT or MRI, and suspected recurrence often requires invasive biopsy procedures.

TRACP-5b is an enzyme associated with osteoclast activity that can be measured from a blood sample. Previous studies suggest that TRACP-5b levels may reflect disease activity and risk of recurrence in patients with GCTB. In this study, patients with newly diagnosed GCTB and patients already undergoing long-term follow-up after treatment will undergo regular blood sampling for TRACP-5b measurement during routine outpatient visits. Laboratory results will be compared with the patient's clinical condition, imaging findings, and histological results when available.

The goal of the study is to determine whether TRACP-5b could become a reliable and minimally invasive tool for earlier detection of disease recurrence and improved long-term monitoring of patients with giant cell tumor of bone.

Conditions

• Giant Cell Tumor of Bone
• TRACP-5b
• Disease Surveillance and Monitoring
• Tartrate-Resistant Acid Phosphatase 5b

Interventions

DIAGNOSTIC_TEST

Tartrate-Resistant Acid Phosphatase 5b

Serial measurement of serum TRACP-5b levels in patients with giant cell tumor of bone during routine outpatient follow-up. Peripheral venous blood samples will be collected at scheduled clinical visits and analyzed using a validated immunochemical assay to evaluate the relationship between TRACP-5b levels, disease activity, treatment response, and local recurrence.

Sponsors & Collaborators

• Department of Clinical Biochemistry, Institute of Laboratory Medicine of the University Hospital Ostrava

  collaborator UNKNOWN

• Department of Clinical Biochemistry, St. Anne's University Hospital Brno, Czech Republic

  collaborator UNKNOWN

• St. Anne's University Hospital Brno, Czech Republic

  lead OTHER

Principal Investigators

• Vasileios Apostolopoulos, M.D., Ph.D. · First Department of Orthopedic Surgery, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czechia

• Michal Mahdal, M.D., Ph.D. · First Department of Orthopedic Surgery, St. Anne's University Hospital and Faculty of Medicine, Masaryk University, Brno, Czechia

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2026-01-01

Primary Completion

2027-12-31

Completion

2028-05-31

Countries

• Czechia

Study Locations