MedTrace Logo

Estimation of the Prevalence of Microcirculatory Dysfunction in Uremic Cardiopathy Among Dialysis Patients

NCT07608679 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-05-27

No results posted yet for this study

Summary

Patients with end-stage renal disease have a high burden of cardiovascular mortality, yet ischemic heart disease is often asymptomatic and difficult to diagnose in this population. Recent data suggest that microvascular coronary dysfunction may contribute significantly to myocardial ischemia in dialysis patients, but its true prevalence remains unknown. This study aims to evaluate microcirculatory coronary impairment in hemodialysis patients using invasive coronary angiography with measurement of coronary flow reserve (CFR), index of microcirculatory resistance (IMR). The study will also describe the clinical and biological characteristics associated with microvascular dysfunction in this population, in order to better understand the mechanisms of uremic cardiomyopathy and improve cardiovascular risk stratification.

Conditions

  • Hemodyalysis

Interventions

DIAGNOSTIC_TEST

Transthoracic ultrasound at rest

Transthoracic ultrasound at rest

DIAGNOSTIC_TEST

Cardiological stress test

Left to the discretion of the centre: dobutamine echocardiography or myocardial scintigraphy.

DIAGNOSTIC_TEST

Coronary angiography

Even even if the stress test comes back normal (these tests appear to be less effective at diagnosing microcirculatory abnormalities)

Sponsors & Collaborators

  • Centre Hospitalier Departemental Vendee

    lead OTHER

Principal Investigators

  • Grégoire COUVRAT-DESVERGNES · Centre Hospitalier Departemental Vendee

Study Design

Allocation
NA
Purpose
SCREENING
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2027-09-30
Primary Completion
2028-06-30
Completion
2028-09-30

Countries

  • France

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07608679 on ClinicalTrials.gov