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Diagnostic Accuracy of 2 cm Versus 4 cm Insertion Depth for Nasal Swabs for SARS-CoV-2 (COVID-19) Rapid Antigen Testing-A Randomized Controlled Trial

NCT07597889 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 317

Last updated 2026-05-19

No results posted yet for this study

Summary

This study aims to compare the diagnostic accuracy of rapid antigen detection tests (RDTs) for SARS-CoV-2 using nasal swab insertion depths of 2 cm versus 4 cm.

The study is an investigator-initiated, randomized clinical trial conducted at a public COVID-19 test center in Copenhagen, Denmark.

Following enrollment, participants complete a questionnaire regarding symptoms and vaccination status.

Participants are randomized in a 1:1 ratio to one of two sampling sequences: either a 2 cm swab in the left nostril and a 4 cm swab in the right nostril, or vice versa. All participants undergo a healthcare worker-collected throat swab for RT-PCR analysis, which serves as the reference standard for SARS-CoV-2 infection.

Conditions

  • COVID -19

Interventions

DIAGNOSTIC_TEST

4 cm nasal swab - left nostril

a 4 cm nasal swab insertion in the left nostril

DIAGNOSTIC_TEST

2 cm nasal swab in the left nostril

a 2 cm nasal swab insertion in the left nostril

DIAGNOSTIC_TEST

4 cm nasal swab - right nostril

a 4 cm nasal swab insertion in the right nostril

DIAGNOSTIC_TEST

2 cm nasal swab - right nostril

a 2 cm nasal swab insertion in the right nostril

Sponsors & Collaborators

  • Rigshospitalet, Denmark

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
16 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-02-01
Primary Completion
2023-02-26
Completion
2023-02-26

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07597889 on ClinicalTrials.gov