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Plasma Exchange Half-dose and Extracorporeal Detoxification for ACLF

NCT07593638 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 240

Last updated 2026-05-18

No results posted yet for this study

Summary

Clinical trial

The goal of this clinical trial is to learn if a liver support protocol works to treat Liver failure in adults. The main questions it aims to answer are:

* Does hemoadsorption plus half-dose plasma exchange provide support to liver failure patients until recovery or transplant
* What medical problems do participants have during the technique? Researchers will compare DPMAS plus half-dose plasma exchange with conventional treatment to evaluate a gain in recovery

Participants will:

* Be submitted to DPMAS plus half dose plasma exchange daily according to protocol.
* Monitoring will be continuous in the ICU

Conditions

  • Acute on Chronic Liver Failure (ACLF)

Interventions

DEVICE

DPMAS plus plasma exchange

Use of extracorporal technique to support patients with acute on chronic liver failure

Sponsors & Collaborators

  • Unidade Local de Saude do Nordeste

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-07-31
Primary Completion
2027-12-31
Completion
2028-01-31

Countries

  • Portugal

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07593638 on ClinicalTrials.gov