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TACTIC-HF: Sequential Diuretic Strategies in Ambulatory Worsening Heart Failure

NCT07593612 · Status: NOT_YET_RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 60

Last updated 2026-05-18

No results posted yet for this study

Summary

TACTIC-HF is a prospective randomized crossover trial designed to compare three ambulatory diuretic strategies in patients with worsening heart failure treated in a specialized heart failure day-hospital program.

Participants will receive sequential treatment with:

1. intravenous furosemide alone,
2. intravenous furosemide combined with oral acetazolamide, and
3. intravenous furosemide combined with oral hydrochlorothiazide.

The primary objective is to compare short-term natriuretic response between strategies. Secondary objectives include assessment of urine output, congestion parameters, and renal/electrolyte safety.

Each participant will undergo repeated outpatient treatment sessions separated by washout periods, with standardized clinical and laboratory monitoring performed during each visit.

The study aims to evaluate pragmatic and clinically applicable ambulatory decongestion strategies using approved therapies commonly available in real-world practice.

Conditions

  • Acute Heart Failure (AHF)

Interventions

DRUG

Intravenous furosemide bolus injections

Intravenous loop diuretic therapy administered during outpatient treatment sessions according to protocol-defined dosing categories.

DRUG

ACETAZOLAMIDE oral capsule

Oral acetazolamide administered prior to intravenous loop diuretic therapy during outpatient treatment sessions

DRUG

Hydrochlorothiazide (HCT)

Oral hydrochlorothiazide administered prior to intravenous loop diuretic therapy during outpatient treatment sessions.

Sponsors & Collaborators

  • Lucrecia Maria Burgos

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-15
Primary Completion
2027-01-15
Completion
2027-01-15

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07593612 on ClinicalTrials.gov