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SNRK & Vascular Endothelial Aging

NCT07591337 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 180

Last updated 2026-05-15

No results posted yet for this study

Summary

Cardiovascular diseases pose a serious threat to public health, and their prevalence is on the rise year by year. Vascular aging is an independent risk factor for cardiovascular diseases, and endothelial cell senescence is an early event in vascular aging. Its occurrence can lead to endothelium-dependent vasodilation dysfunction, reduced vascular permeability, and the release of the senescence-associated secretory phenotype (SASP). These vascular pathological changes further damage the vascular media, leading to vascular remodeling and reduced compliance, accelerating the progression of atherosclerosis, and ultimately resulting in cardiovascular diseases such as coronary heart disease and hypertension. Recent research of the investigators has revealed that SNRK, a new member of the AMPK family of cellular energy sensors, plays a key regulatory role in vascular development. Based on this finding, the investigators propose the scientific hypothesis that SNRK responds to both physiological and pathological aging stimuli through differential mechanisms and regulates the process of endothelial cell senescence. In this study, the investigators will explore the correlation between SNRKAS and carotid vascular structure and endothelial function by measuring the levels of the SNRK upstream lncRNA (SNRKAS) in participants' peripheral blood, in conjunction with carotid ultrasound examinations. The findings will provide a solid scientific basis for elucidating new mechanisms underlying the onset and progression of vascular aging and for identifying novel therapeutic targets.

Conditions

  • Vascular Aging

Interventions

DIAGNOSTIC_TEST

serum tests and carotid ultrasound test

1. 10 mL of venous blood was drawn from each participant to measure blood lipids and serum levels of SNRKAS (using RT-qPCR), and to perform transcriptomic analysis. 2. Carotid ultrasound was used to measure circumferential strain and pulse wave velocity in both carotid arteries to assess the degree of arterial stiffness.

Sponsors & Collaborators

  • Tianjin Medical University

    lead OTHER

Principal Investigators

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2029-04-30
Completion
2029-04-30

Countries

  • China

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07591337 on ClinicalTrials.gov