Correlation Study Between Clinical Phenotype and Pathology of Type 2 Diabetic Nephropathy

Summary

With the rapid increase of diabetic nephropathy worldwide, type 2 diabetes mellitus(DM) is the leading cause of end-stage renal disease(ESRD). Pathological types of diabetic kidney disease(DKD) could be mainly divided into diabetic nephropathy（DN）and non-diabetic renal diseases（NDRD）. There are no accurate renal biopsy indications and standardized operation procedures for type 2 diabetic nephropathy. The clinical stages of type 2 diabetic nephropathy still referred to the Mogensen stage of type 1 diabetic nephropathy. Thus, our study aim to clarify the differences in clinical phenotype between type 2 DN and type 2 NDRD, analysis the correlation between clinical and pathological features, and offer the criteria for clinical staging and prognosis.

Conditions

• Diabetic Kidney Disease

Sponsors & Collaborators

• Beijing Municipal Science & Technology Commission

  collaborator OTHER

• China-Japan Friendship Hospital

  collaborator OTHER

• Beijing Friendship Hospital

  collaborator OTHER

• Beijing Hospital

  collaborator OTHER_GOV

• Fourth Medical Center of PLA General Hospital

  collaborator OTHER

• The Affiliated Nanjing Drum Tower Hospital of Nanjing University Medical School

  collaborator OTHER

• Third Medical Center of PLA General Hospital

  collaborator UNKNOWN

• Shanghai Jiao Tong University Affiliated Sixth People's Hospital

  collaborator OTHER

• The First Affiliated Hospital of Dalian Medical University

  collaborator OTHER

• Daping Hospital and the Research Institute of Surgery of the Third Military Medical University

  collaborator OTHER

• First Teaching Hospital of Tianjin University of Traditional Chinese Medicine

  collaborator OTHER

• Guang'anmen Hospital of China Academy of Chinese Medical Sciences

  collaborator OTHER

• Dongzhimen Hospital, Beijing

  collaborator OTHER

• Shanghai University of Traditional Chinese Medicine

  collaborator OTHER

• Chinese PLA General Hospital

  lead OTHER

Principal Investigators

• Xiangmei Chen, MD.&Ph.D · Chinese PLA General Hospital

Eligibility

Min Age

18 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2017-11-30

Primary Completion

2027-11-30

Completion

2030-12-31

Countries

• China

Study Locations