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How Can Different Forms of Strengthening Exercises Affect the Muscular Tissue and Its Chemical Markers in Children With Duchenne Muscular Dystrophy

NCT07581743 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 45

Last updated 2026-05-12

No results posted yet for this study

Summary

The treatment of patients diagnosed with DMD needs to be multidisciplinary, judicious, and always focused on the patient's well-being. Physiotherapy and occupational therapy are very often standard care. Physiotherapy is regarded as crucial for the success of treatment, since it has achieved good results in the short term, such as maintaining the autonomy of these individuals . Physical activity is another method that has been used to treat DMD. Studies have used physical exercise in individuals with DMD in order to decrease muscle deterioration, muscle contractures, and bone fractures, and to increase the time of functional independence

Conditions

  • Duchene Muscular Dystrophy

Interventions

OTHER

strengthening exercises

Concentric strengthening exercises: involves the muscle producing tension and shortening to move a load Isometric strengthening exercises: occurs when a muscle produces tension without a change in muscle length. Isometric contractions involve sarcomere shortening and increasing muscle tension, but do not move a load Eccentric strengthening exercises: occurs when the muscle tension produced is less than the load and a muscle lengthens while under tension

OTHER

Low-Intensity Exercise Protocol

The children were trained 3 times per week for 8 weeks on a treadmill without inclination, with speed and time programmed and adapted for this purpose. The length of each training activity was 30 min (Andersen et al. 2013; Markert et al. 2012). The children were acclimated to the treadmill for 7 days before the beginning of the training program, with a speed of 4 m/min, in order to minimize the stress caused by the different environment.

OTHER

traditional physical therapy program

traditional physical therapy program to improve strength

Sponsors & Collaborators

  • Cairo University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
6 Years
Max Age
10 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-06-01
Primary Completion
2026-08-15
Completion
2026-09-01

Countries

  • Egypt

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07581743 on ClinicalTrials.gov