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AI-assisted CT for Risk Stratification in Coronary Artery Disease (ACTION)

NCT07577609 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 10000

Last updated 2026-05-11

No results posted yet for this study

Summary

The goal of this observational study is to learn if AI-assisted cardiac CT imaging can improve cardiovascular risk stratification and prediction of future coronary events in an adult population undergoing clinically indicated cardiac CT.

The main questions it aims to answer are:

* Can AI-enhanced cardiac CT accurately assess cardiovascular risk in a real-world adult population?
* How do CT-derived plaque characteristics correlate with clinical, biochemical, and lifestyle risk factors? Researchers will compare subgroups (e.g., patients with different risk profiles, biomarkers, or imaging findings, and a subset undergoing OCT imaging) to see if differences in imaging and clinical parameters are associated with cardiovascular risk and plaque vulnerability.

Participants will:

* Provide informed consent and medical history/demographic information
* Undergo blood sampling for cardiovascular and metabolic biomarkers
* Have a resting ECG performed
* Complete a detailed lifestyle and health questionnaire
* Receive a non-invasive cardiac CT scan interpreted by an expert
* Potentially receive heart rate-lowering medication (e.g., metoprolol) if required for imaging quality
* Be referred for further clinical evaluation if clinically indicated 

Conditions

  • Coronary Artery Disease (CAD)
  • Computed Tomography Angiography
  • Biomarkers
  • AI (Artificial Intelligence)
  • Lipoprotein(a)
  • Atheroscleroses, Coronary
  • Myocardial Ischemia

Sponsors & Collaborators

  • Science Foundation Ireland

    collaborator OTHER

  • University of Galway

    lead OTHER

Principal Investigators

  • Faisal Sharif, MBBS, PhD, FRCPI, FESC, FACC · University of Galway

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-12-21
Primary Completion
2032-12-21
Completion
2032-12-21

Countries

  • Ireland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07577609 on ClinicalTrials.gov