Allogeneic Dental Pulp Stem Cells for the Treatment of Periodontitis
NCT07574840 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30
Last updated 2026-05-08
Summary
The overall objective of this study is to evaluate the safety and efficacy of allogeneic human dental pulp stem cells (DPSCs) injected for the treatment of chronic periodontitis in humans. It aims to develop a stem cell injection therapy that promotes the regeneration of periodontal soft and hard tissues through a non-invasive (minimally invasive) procedure, thereby replacing traditional traumatic periodontal surgery.
Conditions
- Periodontitis
Interventions
- OTHER
-
Allogeneic Dental Pulp Stem Cells for the Treatment of Periodontitis
The overall objective of this study is to evaluate the safety and efficacy of allogeneic human dental pulp stem cells (DPSCs) injected for the treatment of chronic periodontitis in humans. It aims to develop a stem cell injection therapy that promotes the regeneration of periodontal soft and hard tissues through a non-invasive (minimally invasive) procedure, thereby replacing traditional traumatic periodontal surgery.
Sponsors & Collaborators
-
The First Affiliated Hospital of Xinxiang Medical College
lead OTHER
Principal Investigators
-
Wenjie Ren · The First Affiliated Hospital of Xinxiang Medical College
Study Design
- Allocation
- NA
- Purpose
- TREATMENT
- Masking
- NONE
- Model
- SINGLE_GROUP
Eligibility
- Min Age
- 18 Years
- Max Age
- 70 Years
- Sex
- ALL
- Healthy Volunteers
- No
Timeline & Regulatory
- Start
- 2026-04-15
- Primary Completion
- 2027-12-31
- Completion
- 2028-12-31
More Related Trials
-
Safety, Efficacy and Treatment Regimen Study of ST266 in Subjects With Moderate to Severe Periodontitis
NCT02761993 ·Status: COMPLETED ·Phase: PHASE2
-
Safety and Efficacy Study of Allogeneic Human Dental Pulp Mesenchymal Stem Cells to Treat Severe COVID-19 Patients
NCT04336254 ·Status: UNKNOWN ·Phase: PHASE1/PHASE2
-
Injectable PRF in Non-Surgical Periodontal Treatment
NCT07375004 ·Status: ACTIVE_NOT_RECRUITING ·Phase: NA
-
Effects of AMP Application After Non-surgical Periodontal Therapy on Treatment of Periodontitis
NCT05530252 ·Status: COMPLETED ·Phase: PHASE4
-
HA35 Treatment the Gingival Discomfort as Well as Gingival Redness and Bleeding of Patients With Periodontitis
NCT05765513 ·Status: COMPLETED ·Phase: NA
-
A Study to Evaluate the Efficacy and Safety of ALH-L1005 in Patients With Chronic Periodontitis
NCT04503746 ·Status: COMPLETED ·Phase: PHASE2
-
Control of Periodontal Infections
NCT01098448 ·Status: COMPLETED ·Phase: PHASE3
-
Local Injection of Periodontal Pocket Method for the Treatment of Gingivitis
NCT05812300 ·Status: COMPLETED ·Phase: NA
-
Novel Coronavirus Induced Severe Pneumonia Treated by Dental Pulp Mesenchymal Stem Cells
NCT04302519 ·Status: UNKNOWN ·Phase: EARLY_PHASE1
-
Antimicrobial Photodynamic Therapy in Chronic Periodontitis and Diabetes Mellitus
NCT04857346 ·Status: COMPLETED ·Phase: PHASE2/PHASE3
-
Impact of Nonsurgical Periodontal Therapy on Oral Health Related Quality of Life
NCT06143085 ·Status: RECRUITING ·Phase: NA
-
Treatment of Chronic Medium-severe Periodontitis With Mesenchymal Stem Cells Predifferentiated in Osteogenic Direction
NCT04446897 ·Status: COMPLETED ·Phase: PHASE1/PHASE2
-
Clinical Study of a Formulation Containing Phtalox® in Periodontal Disease
NCT05119283 ·Status: COMPLETED ·Phase: NA
-
Emdogain Minimally Invasive Surgical Technique
NCT02551770 ·Status: COMPLETED ·Phase: NA
-
The Effect of Locally Dilvered Ciprofloxacine Loaded Injectable Platelet-rich Fibrin as an Adjunct to Non-surgical Periodontal Therapy on the Gingival Crevicular Level of Interleukin 6
NCT06968286 ·Status: COMPLETED ·Phase: NA
-
Metformin Versus Chlorhexidine Gel as Adjuncts to Scaling and Root Planing in Stage II Grade B Periodontitis
NCT07215156 ·Status: NOT_YET_RECRUITING ·Phase: NA
-
Impact of Non-surgical Periodontal Therapy on Oral and Gut Microbiome
NCT04580355 ·Status: UNKNOWN ·Phase: PHASE4
-
Effects of Probiotic Therapy in the Treatment of Periodontitis.
NCT03408548 ·Status: COMPLETED ·Phase: PHASE2
-
Efficacy and Safety of DKF-306 in Patients With Periodontal Diseases
NCT05188924 ·Status: UNKNOWN ·Phase: PHASE4
-
Clinical Efficacy of 1% Metformin and Alendronate Gel in Adjunct to Fibrin in Chronic Periodontitis
NCT06856369 ·Status: ACTIVE_NOT_RECRUITING ·Phase: PHASE4
-
Serum TRAP-5b Levels in Patients With Generalized Chronic Periodontitis
NCT03043066 ·Status: COMPLETED ·Phase: NA
-
Effects of Periodontal Therapy on Systemic Inflammation
NCT01046435 ·Status: COMPLETED ·Phase: NA
-
Effect of Ozone Gel on Treatment of Chronic Periodontitis
NCT02066337 ·Status: COMPLETED ·Phase: PHASE2
-
Clinical and Metagenomic Investigation of Antimicrobial Peptide Gel in Periodontal Treatment.
NCT05125718 ·Status: COMPLETED ·Phase: EARLY_PHASE1
-
Nitazoxanide as a New Local Adjunctive to Nonsurgical Treatment of Moderate Periodontitis
NCT04768530 ·Status: COMPLETED ·Phase: PHASE2