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RUSS-AGE: Creating of a Biological Age Calculator and Study of Aging Phenotypes in the Russian Population

NCT07574359 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 3500

Last updated 2026-05-07

No results posted yet for this study

Summary

This is a multi-center, cross-sectional, observational study aimed at developing biological age calculators specifically for the Russian population investigating various aging phenotypes.

Aging is a complex process that varies greatly between individuals, meaning that chronological age does not always reflect one's biological health status. The primary goal of this study is to identify and analyze a comprehensive set of markers (including socioeconomic factors, lifestyle, physical parameters, cognitive function, and laboratory biomarkers) that best reflect the aging process. Using this data, researchers will create a mathematical model to estimate a person's "biological age."

The study plans to enroll at least 3,500 male and female volunteers aged 18 years and older from across Russia. Participants will be divided into 5-year age groups (e.g., 18-24, 25-29, up to 90+ years) to ensure broad representation.

Participation involves a single visit to a clinical center. During this visit, participants will undergo:

Interview and questionnaires (assessing health history, lifestyle, socioeconomic status, diet, sleep, and quality of life).

Physical examination and anthropometric measurements (height, weight, blood pressure, grip strength).

Functional and cognitive tests (e.g., walking speed, balance tests, memory and attention tasks tailored to age).

Collection of biomaterials: blood (50 ml), urine, and stool samples for extensive laboratory analysis, including routine tests and specialized aging biomarkers. Part of the biomaterials will be biobanked for future scientific research.

Instrumental examinations for a subset of participants: Depending on the center's capabilities and the study protocol, some participants may also undergo additional assessments such as densitometry (bone density scan), bioimpedance analysis (body composition), and brain MRI.

The results are expected to lead to the creation of a validated biological age calculator for the Russian population. This tool could help identify targets for interventions to promote healthy aging and, in the future, potentially predict the risk of developing age-related chronic diseases.

Conditions

  • Healthy Aging
  • Biomarkers

Sponsors & Collaborators

  • Pirogov Russian National Research Medical University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2023-01-12
Primary Completion
2029-09-30
Completion
2030-09-30

Countries

  • Russia

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07574359 on ClinicalTrials.gov