Longitudinal Assessment of Clinical Course and BIOmarkers in Severe Chronic AIRway Disease

Summary

The aim of the project is to study pathogenetic mechanisms in severe asthma and compare those mechanisms in chronic obstructive pulmonary disease (COPD) in order to test the hypothesis that severe asthma and COPD develop into similar chronic degenerative changes.

Conditions

• Asthma
• COPD

Interventions

DRUG

prednisolone

Prednisolone oral tablets (10 mg active ingredient per tablet) once a day at a dose of 0.5mg/kg bodyweight, during 14 days.

Sponsors & Collaborators

• University of Athens

  collaborator OTHER

• University Hospital of Crete

  collaborator OTHER

• Università degli Studi di Ferrara

  collaborator OTHER

• University Ghent

  collaborator OTHER

• Pulmonary Research Institute Grosshansdorf

  collaborator UNKNOWN

• Leiden University Medical Center

  collaborator OTHER

• Imperial College London

  collaborator OTHER

• Université Montpellier

  collaborator OTHER

• Fondazione C.N.R./Regione Toscana "G. Monasterio", Pisa, Italy

  collaborator OTHER_GOV

• University of Southampton

  collaborator OTHER

• Jagiellonian University

  collaborator OTHER

• Karolinska Institutet

  lead OTHER

Principal Investigators

• Sven-Erik Dahlén, Professor · Karolinska Institutet

Study Design

Allocation

RANDOMIZED

Purpose

BASIC_SCIENCE

Masking

TRIPLE

Model

PARALLEL

Eligibility

Min Age

18 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2002-03-31

Primary Completion

2005-04-30

Completion

2026-12-31

Countries

• Sweden

Study Locations