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Understanding and Tailored Treatment of Low Anterior Resection Syndrome

NCT07573371 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 145

Last updated 2026-05-07

No results posted yet for this study

Summary

The goal of this observational study is to learn why some patients develop low anterior resection syndrome (LARS) after colorectal cancer treatment. The study also aims to identify different subtypes of LARS and understand which patients may respond to specific treatments.

The main questions it aims to answer are:

* What physiological and imaging changes are associated with LARS?
* How do patients with LARS differ from patients without LARS after colorectal cancer surgery?
* Are there measurable differences between LARS, patients treated with organ-preserving chemoradiotherapy, and patients with fecal incontinence?

Participants will:

* Complete advanced physiological and imaging assessments related to bowel function
* Be compared with four control groups:

* patients without LARS after colorectal cancer surgery
* patients treated with organ-preserving chemoradiotherapy
* patients with fecal incontinence and urge fecal incontinence
* Take part in a single study visit where all measurements are performed

Conditions

  • Low Anterior Resection Syndrome
  • Faecal Incontinence With Faecal Urgency
  • Faecal Incontinence
  • Colorectal (Colon or Rectal) Cancer Survivors

Sponsors & Collaborators

  • Aarhus University Hospital

    collaborator OTHER

  • Danish Cancer Society

    collaborator OTHER

  • Vejle Hospital

    collaborator OTHER

  • Aalborg University Hospital

    lead OTHER

Principal Investigators

  • Peter Christensen, MD, Professor · Pelvic Floor Unit, Department of Surgery, Aarhus University Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-09-17
Primary Completion
2026-12-31
Completion
2026-12-31

Countries

  • Denmark

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07573371 on ClinicalTrials.gov