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Cognitive Musical Screening and Therapeutic Innovation in Multiple Sclerosis

NCT07552428 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 32

Last updated 2026-04-27

No results posted yet for this study

Summary

This pilot study evaluates the effectiveness of screening and improving cognitive function in patients with multiple sclerosis (MS) using a musical tool, the Ipsilon. The Ipsilon performance will be compared with established neuropsychological assessments, including the Minimal Assessment of Cognitive Function in MS (MACFIMS) and the Processing Speed Test (PST). Thirty-two participants will be enrolled in a crossover design: half will complete the Ipsilon musical test for 15 minutes daily for seven consecutive days, while the other half will begin with no intervention before switching sequences. Participants will undergo screening for depression, colorblindness, musical background, and upper extremity function. Primary outcomes include evaluating whether the Ipsilon more reliably predicts cognitive domains measured by MACFIMS than the PST and assessing its potential to improve cognitive function. Secondary outcomes will examine associations with work functioning and quality of life.

Conditions

Interventions

BEHAVIORAL

Musical tool (Ipsilon)

The musical tool to assess cognitive function

Sponsors & Collaborators

  • The Cleveland Clinic

    collaborator OTHER

  • Genentech, Inc.

    collaborator INDUSTRY

  • Hunter College of City University of New York

    lead OTHER

Principal Investigators

  • Rachel Galioto, PhD · Cleveland Clinic, MS Mellen Center

  • Aliza Ben-Zacharia, PhD, DNP · Hunter College of City University of New York

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-10-01
Primary Completion
2028-10-01
Completion
2028-12-31

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Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07552428 on ClinicalTrials.gov