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Surfactant Administration Methods in Preterm Infants With RDS: A Swedish Cohort Study

NCT07550218 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 300

Last updated 2026-08-20

No results posted yet for this study

Summary

The goal of this observational study is to evaluate different methods of surfactant administration in preterm infants with respiratory distress syndrome (RDS). Preterm infants often have immature lungs and a deficiency of surfactant, a substance that helps keep the lungs open and supports oxygen exchange.Surfactant can be delivered to the lungs using different techniques, including INSURE (brief intubation), LISA (via a thin catheter), SALSA (via a laryngeal mask airway), and traditional administration via endotracheal intubation followed by mechanical ventilation. The main question this study aims to answer is:Which method of surfactant administration is associated with better clinical outcomes in preterm infants with RDS?The study will prospectively collect clinical data on infants receiving surfactant as part of standard care, with long-term follow-up using data from the Swedish Neonatal Quality Register. The results are intended to be used to inform the design of a future randomized multicenter study.

Conditions

  • Respiratory Distress Syndrome (& [Hyaline Membrane Disease])
  • Respiratory Distress Syndrome (Neonatal)
  • Respiratory Distress Syndrome (RDS)
  • Respiratory Distress Syndrome of Newborn
  • Respiratory Distress Syndrome in Premature Infant

Sponsors & Collaborators

  • Göteborg University

    collaborator OTHER

  • Vastra Gotaland Region

    lead OTHER_GOV

Principal Investigators

  • Anders Elfvin, Professor · Department of Neonatology, Queen Silvia Children's Hospital, Sahlgrenska University Hospital, Gothenburg, Region Västra Götaland, Sweden

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-25
Primary Completion
2029-05-25
Completion
2029-10-25

Countries

  • Sweden

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07550218 on ClinicalTrials.gov