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Real-Time Imaging to Improve Lung Cancer Diagnosis : Comparing Confocal Laser Endomicroscopy (CLE) With Standard Biopsy for Quicker and Safer Detection of Non-Small Cell Lung Cancer

NCT07538947 · Status: RECRUITING · Type: OBSERVATIONAL · Enrollment: 70

Last updated 2026-04-20

No results posted yet for this study

Summary

The goal of this observational study is to evaluate whether confocal laser endomicroscopy (CLE) can improve the real-time diagnosis of non-small cell lung cancer (NSCLC) in patients undergoing bronchoscopic biopsy for suspected lung tumors. The main questions it aims to answer are:

* Can a high-specificity CLE-based score accurately identify NSCLC during endoscopic procedures?
* Can CLE imaging criteria improve biopsy yield and help differentiate histological subtypes (e.g., squamous cell carcinoma, adenocarcinoma, carcinoid tumors)?

Participants will:

* Undergo standard bronchoscopic navigation procedures with additional real-time imaging using CLE and biopsy
* Have CLE findings compared with standard histopathological analysis of biopsy samples

Conditions

  • Non Small Cell Lung Cancer

Interventions

PROCEDURE

bronchoscopic navigation with CLE

bronchoscopic navigation with real-time imagine (Confocal Laser Endomicroscopy)

Sponsors & Collaborators

  • Central Hospital, Nancy, France

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-03
Primary Completion
2026-06-15
Completion
2026-06-15

Countries

  • France

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07538947 on ClinicalTrials.gov