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The Role of Potassium Channels in Working Memory Impairments of Chronic Cocaine Users

NCT07532460 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 40

Last updated 2026-04-20

No results posted yet for this study

Summary

The study aims to address the neurobiological basis of cognitive impairments in chronic cocaine users by investigating the potential impact of an acute potassium channel blockade on working memory performance and other cognitive functions.

Conditions

  • Cocaine Use Disorder (CUD)
  • Cognitive Impairments

Interventions

DRUG

4-aminopyridine (4-AP)

Two doses of fampridine administered during one of the two experimental test sessions.

DRUG

Placebo

Matching placebo administered during one of the two experimental test sessions.

Sponsors & Collaborators

  • University of Zurich

    collaborator OTHER

  • Boris Quednow

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
CROSSOVER

Eligibility

Min Age
20 Years
Max Age
50 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2027-08-31
Completion
2027-08-31

Countries

  • Switzerland

Study Locations

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Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07532460 on ClinicalTrials.gov