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Outcome of Primary vs Delayed Primary Closure of Laparotomy in Dirty Abdominal Wounds

NCT07531576 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 78

Last updated 2026-04-15

No results posted yet for this study

Summary

This randomized controlled trial is designed to evaluate and compare two different wound management strategies-primary closure (PC) and delayed primary closure (DPC)-in patients undergoing emergency laparotomy for peritonitis

* The primary objective is to determine which technique more effectively reduces postoperative complications, specifically surgical site infections (SSI) and wound dehiscence (burst abdomen), while also assessing the impact on the length of hospital stay (LOS)

The study includes 78 patients aged 15 to 80 years with free intraperitoneal contamination

* In the PC group, the abdominal wound is closed immediately following the procedure
* In the DPC group, the skin and subcutaneous tissues are initially left open to allow for drainage and are washed twice weekly until the wound is free of contamination (pus, fecal matter, bile, or blood), at which point it is closed using tension sutures
* This study aims to provide clinical evidence on whether the biological benefits of DPC-such as reduced bacterial colonization and improved drainage-outweigh the potential drawbacks of the technique, such as patient discomfort or prolonged care

Conditions

  • Peritonitis
  • Primary Closure
  • Delayed Primary Closure

Interventions

PROCEDURE

Delayed Primary Laparotomy wound Closure

This technique involves leaving the skin and subcutaneous tissues open for several days following the initial surgery

PROCEDURE

Primary Abdominal Closure

In this intervention, the skin and subcutaneous tissues are closed immediately following the completion of the emergency laparotomy

Sponsors & Collaborators

  • Ayub Teaching Hospital

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
15 Years
Max Age
80 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2021-02-17
Primary Completion
2021-06-21
Completion
2021-06-21

Countries

  • Pakistan

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07531576 on ClinicalTrials.gov