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Risk of Scrotal Hydroceles After Nephrectomy For Kidney Cancer

NCT07527637 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 40000

Last updated 2026-06-09

No results posted yet for this study

Summary

This population-based study will use provincial health administrative data to examine the risk of hospital admission for hydrocelectomy among males who underwent nephrectomy for kidney cancer, compared with males from the general population with similar baseline health characteristics, who did not undergo nephrectomy. We will use health administrative data from Ontario, Canada, to identify males who underwent nephrectomy for kidney cancer between 2002 and 2024. Four surgical cohorts will be constructed based on procedure type and surgical approach: laparoscopic total nephrectomy, open total nephrectomy, laparoscopic partial nephrectomy, and open partial nephrectomy. A propensity score will be calculated based on sociodemographic characteristics, comorbidities, and health care utilization. For each surgical cohort, patients will be matched to non-nephrectomy male controls (1:4) based on propensity score, age, index date, and modified Charlson Score (excluding cancer). The primary analysis will compare patients undergoing laparoscopic total nephrectomy and laparoscopic partial nephrectomy with matched non-nephrectomy controls from the general population. The primary outcome is hospital admission for hydrocelectomy. Secondary outcomes include diagnosis of hydrocele with receipt of a scrotal ultrasound, and receipt of a scrotal ultrasound. Additional analyses will compare surgical approaches.

Conditions

  • Hydrocele
  • Hydrocele of Tunica Vaginalis
  • Hydrocelectomy
  • Nephrectomy
  • Laparoscopic Nephrectomy
  • Kidney Cancers

Interventions

PROCEDURE

Laparoscopic nephrectomy for kidney cancer

Receipt of a laparoscopic (total or partial) nephrectomy for kidney cancer

PROCEDURE

Open nephrectomy for kidney cancer

Receipt of an open (total or partial) nephrectomy for kidney cancer

Sponsors & Collaborators

  • London Health Sciences Centre Research Institute OR Lawson Research Institute of St. Joseph's

    lead OTHER

Eligibility

Min Age
0 Years
Max Age
105 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2002-04-01
Primary Completion
2024-03-31
Completion
2025-03-31

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07527637 on ClinicalTrials.gov