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Could miRNAs be Used as Markers for Distinguishing Undescended Testicles From Retractile Testicles

NCT07315737 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 28

Last updated 2026-01-02

No results posted yet for this study

Summary

Background: Undescended testicles (UDTs) are common in male infants. Untreated UDT poses risks such as infertility (IF), testicular cancer (TC), and testicular torsion (TT). Retractile testicles (RTs) sporadically ascend from the scrotum. UDT requires early surgical correction, whereas RT requires only periodic follow-up. Differentiating these conditions is challenging, making clinical biomarkers potentially useful. The aim of our study was to examine the use of miRNAs, which are difficult to differentiate, as biomarkers in the differential diagnosis of UDT and RT.

Methods: This prospective study included 10 boys with UDT (operated), 9 with RT (followed), and 9 controls. Parent consent and serum samples were collected to evaluate miR-210, miR-34c, and miR-449a expression via real-time PCR. For group comparisons, one-way ANOVA was used for parametric data, and the Kruskal-Wallis test was used for nonparametric data, followed by the Dunn-Bonferroni correction for post hoc multiple comparisons. Spearman's rank correlation coefficient was used to analyse correlations. A p value \< 0.05 was considered significant.

Conditions

  • MIRAS
  • Testicular Abnominalies
  • Undescended Testes

Interventions

DIAGNOSTIC_TEST

miRNA

miR-34c , miR-210 , miR-449a levels investigated.

Sponsors & Collaborators

  • Dr. Mevlüt Keleş

    lead OTHER

Principal Investigators

  • Benli · Ordu University

Eligibility

Min Age
3 Months
Max Age
18 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2022-03-01
Primary Completion
2023-03-31
Completion
2023-04-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07315737 on ClinicalTrials.gov