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Pain & Reward Neuromodulation of CNS Circuits

NCT07525063 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 30

Last updated 2026-04-13

No results posted yet for this study

Summary

This pilot feasibility study aims to evaluate transcranial magnetic stimulation (TMS) targeting the prefrontal cortex in patients with fibromyalgia syndrome (FMS). The study will assess preliminary efficacy and mechanisms of central nervous system changes using neuroimaging, behavioral tasks, sensory testing, and neuroimmune markers. Participants will undergo MRI scans, multi-day TMS sessions, and complete questionnaires. The goal is to generate pilot data for future trials on neuromodulation for chronic pain.

Conditions

  • Fibromyalgia Syndrome
  • Fibromyalgia
  • Chronic Pain and Fatigue

Interventions

DEVICE

Transcranial Magnetic Stimulation (TMS)

TMS protocol delivered via MagPro X100 stimulator with figure-8 coil targeting prefrontal cortex.

Sponsors & Collaborators

  • American Fibromyalgia Syndrome Association

    collaborator OTHER

  • Duke University

    lead OTHER

Principal Investigators

  • Katherine T Martucci, PhD · Duke University

Study Design

Allocation
NA
Purpose
TREATMENT
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
FEMALE
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-31
Primary Completion
2026-12-31
Completion
2027-06-30
FDA Device
Yes

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07525063 on ClinicalTrials.gov