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taVNS During Exercise and Recovery in Chronic Spinal Cord Injury

NCT07524491 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 35

Last updated 2026-04-13

No results posted yet for this study

Summary

This study investigates the effects of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic cardiovascular regulation during exercise and recovery in individuals with chronic spinal cord injury (SCI). Participants undergo two experimental conditions (active taVNS and sham stimulation) in a randomized crossover design while performing a standardized exercise protocol.

Heart rate variability (HRV) is used as a non-invasive biomarker to assess autonomic nervous system dynamics across different phases (baseline, exercise, and recovery). The aim is to characterize physiological responses to neuromodulation and explore whether taVNS modulates autonomic adaptability in this population.

This is a mechanistic physiological study designed to improve the understanding of autonomic regulation in SCI and to explore potential biomarkers of response to neuromodulation.

Conditions

  • Spinal Cord Injury, Chronic

Interventions

DEVICE

Transcutaneous Auricular Vagus Nerve Stimulation

Non-invasive electrical stimulation applied to the auricular branch of the vagus nerve using transcutaneous electrodes during the experimental protocol.

DEVICE

Sham Stimulation

Sham stimulation delivered with identical device setup but without effective activation of the vagus nerve.

Sponsors & Collaborators

  • Health Research Institute of the Balearic Islands (IdISBa, Spain)

    collaborator UNKNOWN

  • University of the Balearic Islands - Institute for Health Sciences Research (UNICS)

    collaborator UNKNOWN

  • University of the Balearic Islands

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
70 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2024-10-31
Primary Completion
2024-10-31
Completion
2024-10-31

Countries

  • Spain

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07524491 on ClinicalTrials.gov