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Different Frequency Applications of Transcutaneous Auricular Vagus Nerve Stimulation in Healthy Individuals

NCT07526402 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 36

Last updated 2026-04-16

No results posted yet for this study

Summary

This randomized, participant-blinded, sham-controlled crossover study aims to investigate the acute effects of different frequency applications of transcutaneous auricular vagus nerve stimulation (taVNS) on autonomic physiological responses in healthy adults. Participants will receive sham (0 Hz), 10 Hz, 25 Hz, 50 Hz, and 100 Hz taVNS in separate sessions with washout periods between visits. Heart rate variability, blood pressure, pulse rate, respiratory rate, and subjective discomfort will be assessed before and after each intervention session.

Conditions

  • Healthy Volunteers

Interventions

DEVICE

Sham taVNS

Sham stimulation is delivered under conditions similar to active taVNS without meaningful vagal stimulation.

DEVICE

taVNS 10 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 10 Hz.

DEVICE

taVNS 25 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 25 Hz.

DEVICE

taVNS 50 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 50 Hz.

DEVICE

taVNS 100 Hz

Active transcutaneous auricular vagus nerve stimulation applied for 10 minutes at 100 Hz.

Sponsors & Collaborators

  • Sinop University

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
SINGLE
Model
CROSSOVER

Eligibility

Min Age
18 Years
Max Age
40 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2026-05-01
Completion
2026-09-01

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07526402 on ClinicalTrials.gov