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Comparison of the Effects of Desflurane-Remifentanyl and Propofol-Remifentanyl Anesthesia on Intraoperative Cerebral Oxygenation in Patients Undergoing Laparoscopic Cholecystectomy

NCT07517146 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 84

Last updated 2026-04-08

No results posted yet for this study

Summary

Study Population:

Patients undergoing elective laparoscopic cholecystectomy under general anesthesia will be included.

Study Design:

This is an observational study. No interventions outside routine clinical practice will be applied. All procedures will be performed by experienced anesthesiologists according to standard institutional protocols.

Data Collection

Preoperative Data:

The following variables will be recorded from anesthesia charts:

Demographics: age, sex, height, weight, body mass index (BMI) Education level Smoking, alcohol, and substance use status Routine preoperative laboratory tests

Clinical scores:

Charlson Comorbidity Index (CCI) Beck Anxiety Scale ARISCAT Score STOP-BANG Score Montreal Cognitive Assessment (MoCA) ASA Physical Status Classification

Intraoperative Data:

Patients will be observed in two groups based on anesthesia technique:

Desflurane + remifentanyl Total intravenous anesthesia (TIVA: propofol + remifentanyl)

The following parameters will be recorded:

Hemodynamic data: blood pressure, heart rate Oxygenation parameters: SpO₂, SpO₂/FiO₂ ratio Cerebral and depth monitoring: NIRS, BIS Respiratory mechanics Oxygen Saturation Index (OSI = \[Pmean × FiO₂\] / SpO₂) Mechanical ventilator parameters

Time Points for Measurement:

Before induction After induction After intubation Every 20 minutes intraoperatively After extubation

Additional Intraoperative Variables:

Duration of surgery and anesthesia

Total anesthetic drug consumption:

Desflurane and remifentanyl Propofol and remifentanyl (TIVA group) Intraoperative blood transfusion (yes/no) Total blood loss Urine output Recovery time Postoperative Follow-up ICU admission (planned or unplanned)

Pain assessment using Numeric Rating Scale (NRS):

PACU Postoperative 1st, 3rd, 6th, 12th, and 24th hours

Postoperative Complications:

Nausea and vomiting Hypotension Arrhythmia (bradycardia, tachycardia) Pulmonary edema Atelectasis Pneumonia Pneumothorax Pleural effusion Cognitive dysfunction

Other Outcomes:

Postoperative MoCA and Beck Anxiety Scale scores Length of hospital stay Length of ICU stay (if applicable) Mortality during follow-up

Conditions

  • ıntraoperative Cerebral Oxygenation
  • Cerebral Oxygenation Monitoring

Sponsors & Collaborators

  • Ankara Ataturk Sanatorium Training and Research Hospital

    lead OTHER_GOV

Principal Investigators

  • Hilal Sazak, Prof. Dr · Ankara Ataturk Sanatorium Training and Research Hospital

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-04-06
Primary Completion
2026-08-31
Completion
2026-09-30

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07517146 on ClinicalTrials.gov