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Vitamin K for Perioperative Warfarin Management

NCT07515664 · Status: RECRUITING · Phase: PHASE4 · Type: INTERVENTIONAL · Enrollment: 20

Last updated 2026-04-13

No results posted yet for this study

Summary

This is a feasibility study of uninterrupted warfarin with a one time dose of Vitamin K before a surgical procedure.

Conditions

  • Anticoagulant Therapy

Interventions

DRUG

Vitamin K

10 mg of oral vitamin K will be given approximately 36-48 hours before procedure.

DRUG

Warfarin (standard without loading)

Patients receive their standard warfarin dosing without interruption.

DRUG

Warfarin (standard with loading)

Patients receive their standard warfarin dosing without interruption; patients also receive a one time loading dose (twice normal dose) of warfarin on the evening following their procedure.

Sponsors & Collaborators

Principal Investigators

  • Geoffrey Barnes, MD · University of Michigan

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-07-03
Primary Completion
2026-08-31
Completion
2026-08-31
FDA Drug
Yes

Countries

  • United States

Study Locations

More Related Trials

Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07515664 on ClinicalTrials.gov