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Autologous Exosomes From Platelet-rich Plasma as a Modern Tool of Regenerative Dentistry

NCT07511959 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 68

Last updated 2026-04-06

No results posted yet for this study

Summary

The aim of the research is the laboratory assessment of the content as well as the regenerative and anti-inflammatory potential of autologous exosomes (EXO) from platelet-rich plasma, as well as their comparison with other autologous products used in intra-articular injections (PRP, PRF).

The material for the research will be obtained from patients of the Temporomandibular Joint Dysfunction Clinic at the University Dental Center in Wrocław with chronic pain of the temporomandibular joints and/or masticatory muscles and/or chronic disturbances in temporomandibular joint mobility, as well as from healthy individuals.

In the subsequent stages, the biological material will be analyzed under laboratory conditions to compare the composition and biological properties of PRF, PRF and EXO.

Conditions

  • Temporomandibular Disorders (TMD)
  • Muscle Pain
  • TMJ Pain

Interventions

DIAGNOSTIC_TEST

Laboratory analysis of the content and biological activity of PRP, PRF, and exosomes obtained from blood samples

Laboratory analysis include in vitro tests aimed to: (1) evaluation of the size and concentration of exosomes, (2) the measurement of the level of cytokines and growth factors in the samples of PRP, PRF and EXO, (3) comparison of the impact of exosomes, PRF and PRP (from the study and control groups) on the proliferation and migration of human chondrocytes and fibroblasts.

Sponsors & Collaborators

  • Wroclaw Medical University

    lead OTHER

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-30
Primary Completion
2027-12-31
Completion
2027-12-31

Countries

  • Poland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07511959 on ClinicalTrials.gov