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Methotrexate Treatment in Hand Osteoarthritis Refractory to Usual Treatments

NCT07501507 · Status: NOT_YET_RECRUITING · Phase: PHASE2/PHASE3 · Type: INTERVENTIONAL · Enrollment: 170

Last updated 2026-03-30

No results posted yet for this study

Summary

Randomized study comparing the structural efficacy of methotrexate versus placebo in digital osteoarthritis

Conditions

  • Erosive Hand Osteoarthritis

Interventions

DRUG

Methotrexate Injectable Solution

Injection of methotrexate every week during 12 month

DRUG

Placebo

The placebo consists of a 0.9% solution of sodium chloride (NaCl) in sterile distilled water for injection. This solution was chosen as the placebo. Injection every week during 12 month.

Sponsors & Collaborators

  • Centre Hospitalier Universitaire de Nice

    lead OTHER

Principal Investigators

  • Yacine ALLAM, Dr · Centre Hospitalier Universitaire de Nice

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
40 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-02
Primary Completion
2027-10-31
Completion
2027-10-31

Countries

  • France

Study Locations

More Related Trials

Entities

Drugs

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07501507 on ClinicalTrials.gov