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Association of Serum VEGF-A and VCAM-1 Levels With Nailfold Capilleroscopic Alterations in Alopecia Areata

NCT07499713 · Status: ENROLLING_BY_INVITATION · Type: OBSERVATIONAL · Enrollment: 90

Last updated 2026-03-30

No results posted yet for this study

Summary

The goal of this observational study is to learn about microvascular changes and hair follicle activity in patients with alopecia areata. The main questions it aims to answer are:

Do blood levels of markers related to blood vessel formation (VEGF-A) and inflammation (VCAM-1) differ between patients with alopecia areata and healthy individuals?

Is there a link between these blood markers and structural changes in the nailfold capillaries?

How do these markers relate to specific trichoscopic signs of disease activity (such as black dots or exclamation mark hairs) and the overall severity of hair loss (SALT score)?

Researchers will compare patients with alopecia areata (grouped by disease duration: acute \<6 months vs. chronic \>6 months) to healthy volunteers to see if there is a significant difference in systemic and local vascular indicators.

Participants will:

Undergo a trichoscopic scalp examination to identify markers of disease activity (black dots, yellow dots, exclamation mark hairs) and calculate the SALT score.

Have their nailfolds examined with a digital capillaroscope (50x) to detect microvascular alterations.

Provide a blood sample to measure the levels of VEGF-A and VCAM-1.

Conditions

Interventions

DIAGNOSTIC_TEST

Microvascular Imaging

his intervention focuses on the integration of microvascular and biochemical markers to phenotype Alopecia Areata subgroups.

DIAGNOSTIC_TEST

Biochemical Biomarker Analysis

Collection of 5-10 mL venous blood samples. Serum is separated by centrifugation (3000 RPM, 10 min) and analyzed via Enzyme-Linked Immunosorbent Assay (ELISA) to determine the levels of Vascular Endothelial Growth Factor A and Vascular Cell Adhesion Molecule 1.

DIAGNOSTIC_TEST

Trichoscopic Imaging

his non-invasive procedure focuses on identifying specific trichoscopic patterns associated with Alopecia Areata activity, including yellow dots, black dots, exclamation mark hairs, and broken hairs.

Sponsors & Collaborators

  • Istanbul Training and Research Hospital

    lead OTHER_GOV

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-04-01
Primary Completion
2026-06-01
Completion
2026-07-01

Countries

  • Turkey (Türkiye)

Study Locations

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Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07499713 on ClinicalTrials.gov