Long-term Prospective Study of Korean CADASIL Patients

Summary

K-CADASIL is a 10-year prospective study of 500 Korean patients with cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a genetic brain disease that causes stroke and dementia. The investigators will track symptoms, brain scans, memory tests, and gene information to understand disease progression in Koreans and identify better treatments. Participants will visit clinics regularly for check-ups and blood tests. This study aims to help improve care for CADASIL patients and families worldwide.

Conditions

• CADASIL
• Cerebral Autosomal Dominant Arteriopatie With Subcortical Infarcts and Leukoencephalopathy

Sponsors & Collaborators

• Asan Medical Center

  collaborator OTHER

• Chonnam National University Hospital

  collaborator OTHER

• Chungbuk National University Hospital

  collaborator OTHER

• Dong-A University Hospital

  collaborator OTHER

• Ewha Woman University Medical Center

  collaborator UNKNOWN

• Hallym University Medical Center

  collaborator OTHER

• Hanyang University Seoul Hospital

  collaborator OTHER

• Inje University Ilsan Paik Hospital

  collaborator OTHER

• Kangdong Sacred Heart Hospital

  collaborator OTHER

• Keimyung University Dongsan Medical Center

  collaborator OTHER

• Korea University Ansan Hospital

  collaborator OTHER

• Korea University Guro Hospital

  collaborator OTHER

• Kyung Hee University Hospital

  collaborator OTHER

• Kyungpook National University Hospital

  collaborator OTHER

• Nowon Eulji Medical Center

  collaborator OTHER

• Pusan National University Hospital

  collaborator OTHER

• Seoul Medical Center

  collaborator OTHER

• Seoul National University Bundang Hospital

  collaborator OTHER

• Seoul National University Hospital

  collaborator OTHER

• Severance Hospital

  collaborator OTHER

• Soonchunhyang University Hospital

  collaborator OTHER

• Ulsan University Hospital

  collaborator OTHER

• Yeungnam University Hospital

  collaborator OTHER

• Daejeon Eulji University Medical Center

  collaborator OTHER

• Jeonbuk National University Hospital

  collaborator UNKNOWN

• DongGuk University

  collaborator OTHER

• Jeju National University Hospital

  lead OTHER

Eligibility

Min Age

19 Years

Sex

ALL

Healthy Volunteers

No

Timeline & Regulatory

Start

2023-07-10

Primary Completion

2035-12-31

Completion

2040-12-31

Countries

• South Korea

Study Locations