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The Effect of the Valsalva Maneuver in Endometrial Biopsy: A Randomized Controlled Trial

NCT07496905 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-08-18

No results posted yet for this study

Summary

Endometrial sampling with a pipelle is a common procedure used to collect a small sample from the lining of the uterus. During the procedure, the cervix is sometimes held with a surgical instrument called a tenaculum, which may cause pain and anxiety for some women.

The Valsalva maneuver is a simple technique in which a person takes a deep breath and pushes as if trying to exhale forcefully. This increases pressure inside the abdomen and may help keep the uterus and cervix more stable during the procedure.

This study aims to compare pipelle sampling performed with the Valsalva maneuver to the standard method using a tenaculum. The study will evaluate whether the Valsalva maneuver can reduce pain and anxiety while maintaining procedure success and improving patient satisfaction.

Conditions

  • Pain in Endometrial Biopsy
  • Abnormal Uterine Bleeding

Interventions

PROCEDURE

endometrial biopsy

Endometrial sampling performed using a pipelle cannula.

PROCEDURE

Tenaculum Application

Application of a tenaculum to the cervix to stabilize it during endometrial biopsy.

PROCEDURE

Valsalva Maneuver

Patients perform the Valsalva maneuver during endometrial biopsy to reduce perceived pain.

Sponsors & Collaborators

  • Prof. Dr. Cemil Tascıoglu Education and Research Hospital Organization

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
OTHER
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-01-01
Primary Completion
2026-06-20
Completion
2026-06-21

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07496905 on ClinicalTrials.gov