MedTrace Logo

Five-Year CT Follow-Up of Vertebral Fracture Risk Using Opportunistic Osteoporosis Screening

NCT07487688 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 2799

Last updated 2026-03-31

No results posted yet for this study

Summary

This study evaluates whether opportunistic osteoporosis screening using routinely acquired computed tomography (CT) scans improves fracture risk prediction compared with guideline-recommended FRAX-based screening from age 50. In current practice, few high-risk individuals identified by FRAX actually receive confirmatory dual-energy X-ray absorptiometry (DXA), despite the growing health and economic burden of osteoporotic fractures. Volumetric bone mineral density (vBMD) and CT-based detection of vertebral fractures can be extracted from existing CT images obtained for other indications, offering a non-invasive way to capture key determinants of fracture and mortality risk, including low BMD, age, and prevalent fractures. The trial therefore compares the diagnostic performance of FRAX major osteoporotic fracture risk versus CT-derived vBMD and CT-identified vertebral fractures for predicting incident vertebral fractures in older adults.

Conditions

  • Osteoporosis
  • Fracture Risk Assessment
  • Osteoporotic Fracture of Vertebra

Interventions

DIAGNOSTIC_TEST

Opportunistic osteoporosis screening

Automatic assessment of CT-based biomarkers of bone health

Sponsors & Collaborators

  • Technical University of Munich

    lead OTHER

Eligibility

Min Age
40 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2003-02-25
Primary Completion
2021-10-15
Completion
2021-10-15

Countries

  • Germany

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07487688 on ClinicalTrials.gov