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GCF Volume Changes in Aligners and Fixed Appliances

NCT07480538 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 32

Last updated 2026-03-18

No results posted yet for this study

Summary

Orthodontic tooth movement induces biological responses in periodontal tissues that can be reflected by changes in gingival crevicular fluid (GCF). This study aims to evaluate temporal changes in GCF volume during orthodontic treatment with clear aligners and conventional fixed appliances. GCF samples will be collected from the buccal site of tooth 12 and the palatal site of tooth 16 at baseline, 1 hour, 1 day, 1 week, and 1 month after appliance placement. The findings of this study will help to better understand periodontal tissue responses associated with different orthodontic treatment modalities.

Conditions

  • Orthodontic Tooth Movement

Interventions

DEVICE

Clear Aligner Therapy

Orthodontic treatment performed using removable clear aligner appliances that deliver controlled orthodontic forces for tooth movement. Participants will wear sequential aligners according to the treatment protocol, and gingival crevicular fluid samples will be collected at predefined time points to evaluate temporal changes in GCF volume.

DEVICE

Fixed Appliance

Orthodontic treatment performed using conventional fixed orthodontic appliances consisting of brackets and archwires to apply continuous orthodontic forces for tooth movement. Gingival crevicular fluid samples will be collected at predefined time points to evaluate temporal changes in GCF volume during treatment.

Sponsors & Collaborators

  • Suleyman Demirel University

    lead OTHER

Study Design

Allocation
NON_RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
PARALLEL

Eligibility

Min Age
14 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-03
Primary Completion
2026-02-11
Completion
2026-03-03

Countries

  • Turkey (Türkiye)

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07480538 on ClinicalTrials.gov