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The Effects of High-dose Vitamin B6 on Depression and Anxiety Symptoms

NCT07469462 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 44

Last updated 2026-04-28

No results posted yet for this study

Summary

This clinical trial investigates the effects of Vitamin B6 supplementation on neural inhibition using electroencephalography (EEG), in relation to depression and anxiety symptoms in participants from the general population with a relatively high level of symptoms at baseline. Researchers will compare a placebo group to high-dose Vitamin B6 to test the hypothesis that Vitamin B6 moves the excitation/inhibition balance towards inhibition.

Conditions

Interventions

DRUG

Pyridoxal-5'-Phosphate supplement

100mg PLP in the form of a tablet, taken once a day for 1 week

DRUG

Placebo Supplementation

Placebo supplement in the form of a capsule.

Sponsors & Collaborators

  • eBeauty Ltd Innopure, Regus House, Cardiff Gate Business Park, Malthouse Avenue, Cardiff, CF23 8RU

    collaborator UNKNOWN

  • University of Reading

    lead OTHER

Principal Investigators

  • David T Field · University of Reading

Study Design

Allocation
RANDOMIZED
Purpose
BASIC_SCIENCE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
41 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2026-11-30
Completion
2026-11-30

Countries

  • United Kingdom

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07469462 on ClinicalTrials.gov