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Non-invasive Brain Stimulation Using Tdcs of the Third (of Many) Visual Pathways

NCT07469384 · Status: RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 120

Last updated 2026-03-13

No results posted yet for this study

Summary

This study investigates the ability of transcranial direct current stimulation (tDCS) applied over the motion processing area of the brain (area MT) to improve face emotion recognition (FER) ability. tDCS is a type of non-invasive brain stimulation in which low level currents are applied over the scalp to influence underlying brain function. In schizophrenia, impaired ability to detect facial motion has been shown to contribute to impaired FER, which, in turn, leads to difficulties in social cognition and poor social outcome. The study will use both fMRI and EEG to measure brain function while participants view moving dot and dynamic face stimuli. Analyses will compare changes in fMRI and EEG activity in individuals receiving active vs. sham stimulation.

Conditions

  • SCHIZOPHRENIA 1 (Disorder)
  • Schizo Affective Disorder

Interventions

DEVICE

transcranial direct current stimulation

tDCS will be applied over cortical region MT+

DEVICE

Sham stimulation

Ramp up/ramp down to simulate scalp sensation associated with tDCS. No sustained current flow

Sponsors & Collaborators

  • National Institute of Mental Health (NIMH)

    collaborator NIH

  • Columbia University

    collaborator OTHER

  • Research Foundation for Mental Hygiene, Inc.

    collaborator OTHER

  • Nathan Kline Institute for Psychiatric Research

    lead OTHER

Principal Investigators

  • Daniel C Javitt, MD, PhD · Nathan Kline Institute

  • Antigona Martinez, PhD · Nathan Kline Institute

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
QUADRUPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
55 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-01
Primary Completion
2030-04-30
Completion
2030-07-31
FDA Device
Yes

Countries

  • United States

Study Locations

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Entities

Companies

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07469384 on ClinicalTrials.gov