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A Study to Find and Confirm Blood-based Markers (Called Proteins) That May Show Early Heart Changes in Women With Preeclampsia, Even Before Symptoms Appear, and the Use of Heart Ultrasound (Echocardiography) to Look at Patterns of How the Heart Changes During Pregnancy in Women With Preeclampsia.

NCT07463898 · Status: NOT_YET_RECRUITING · Type: OBSERVATIONAL · Enrollment: 172

Last updated 2026-03-11

No results posted yet for this study

Summary

The goal of this study is to find and confirm blood-based markers (called proteins) that may show early heart changes in women with preeclampsia, even before symptoms appear. It will also use heart ultrasound (echocardiography) to look at patterns of how the heart changes during pregnancy in women with preeclampsia. The main questions it aims to answer are:

* Do these blood markers relate to heart changes on ultrasound?
* How may they help predict future health problems for the mother?

Participants will:

* Complete a 20-minute survey that will include taking your baseline demographic information, clinical information/medical history, asking about pre-existing health conditions, including measuring your height, weight, and blood pressure.
* Have transthoracic echocardiography (TTE) performed at 12 - 16 weeks gestation and again at 28 - 32 weeks gestation.
* Provide a blood sample for these protein measurements. These samples will be collected at intake (12 - 16 weeks gestation) and again at 28 - 32 weeks gestation.

Conditions

  • Cardiovascular Biomarkers
  • Preeclampsia (PE) Risk
  • Preeclampsia (PE)

Interventions

OTHER

No Intervention: Observational Cohort

This is an observational study, and there is no intervention.

Sponsors & Collaborators

  • Vanderbilt University Medical Center

    collaborator OTHER

  • University of Abuja Teaching Hospital

    collaborator OTHER

  • Washington University School of Medicine

    lead OTHER

Eligibility

Min Age
13 Years
Max Age
50 Years
Sex
FEMALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2026-03-31
Primary Completion
2027-05-31
Completion
2027-12-31

Countries

  • Nigeria

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07463898 on ClinicalTrials.gov