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Effect of Control Ventilation, PEEP, and PEEP With ARM in Robot-assisted Radical Prostatectomy

NCT07462689 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 58

Last updated 2026-03-10

No results posted yet for this study

Summary

The goal of this clinical trial is to determine whether different ventilatory strategies improve oxygenation and hemodynamic stability in patients undergoing robot-assisted radical prostatectomy under general anesthesia. The study will also evaluate the safety and physiological effects of applying positive end-expiratory pressure (PEEP) and alveolar recruitment maneuver (ARM) during surgery.

The main questions this study aims to answer are:

Does the application of PEEP or PEEP combined with ARM improve intraoperative oxygenation compared with conventional mechanical ventilation?

How do PEEP and ARM affect intraoperative hemodynamic parameters such as cardiac output and stroke volume during pneumoperitoneum and steep Trendelenburg positioning?

Are there any adverse events associated with the use of these ventilatory strategies during surgery?

Researchers will compare three ventilation strategies-conventional ventilation without PEEP, ventilation with PEEP alone, and ventilation with PEEP combined with ARM-to evaluate their effects on perioperative oxygenation and cardiovascular function.

Participants will:

Undergo robot-assisted radical prostatectomy under general anesthesia

Be randomly assigned to receive one of three ventilatory strategies during surgery

Receive standardized anesthetic management and intraoperative monitoring

Have arterial blood gas analysis and hemodynamic measurements performed at predefined time points during surgery and recovery

Conditions

  • Robot-Assisted Radical Prostatectomy

Interventions

OTHER

PEEP group

Volume-controlled ventilation with PEEP of 5 cmH₂O applied throughout the procedure, without ARM.

OTHER

PEEP + ARM group

Volume-controlled ventilation with ARM followed by maintenance PEEP of 5 cmH₂O.

Sponsors & Collaborators

  • Ilsan Cha hospital

    lead OTHER

Principal Investigators

  • Eun Young Park · clinical professor

Study Design

Allocation
RANDOMIZED
Purpose
SUPPORTIVE_CARE
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
20 Years
Sex
MALE
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2020-12-01
Primary Completion
2024-02-29
Completion
2024-02-29

Countries

  • South Korea

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07462689 on ClinicalTrials.gov