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Perioperative Prophylactic Positive Pressure Ventilation Reduces Postoperative Pulmonary Complications.

NCT07461285 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 206

Last updated 2026-03-10

No results posted yet for this study

Summary

The incidence of postoperative pulmonary complications (PPCs) ranges from 5% to 33%. PPCs significantly prolong hospital stay, increase the economic burden, and are associated with postoperative mortality at 30 days and 1 year. The occurrence of PPCs is associated with multiple perioperative factors. A multimodal approach may provide better prevention against PPCs. We hypothesize that perioperative prophylactic positive pressure ventilation can reduce the incidence of PPCs in patients undergoing high-risk abdominal surgery.

Conditions

  • Postoperative Pulmonary Complications (PPCs)

Interventions

OTHER

Conventional Ventilation

No PEEP is applied during anesthesia induction; conventional PEEP of 5 cmH₂O is used during surgery; and after tracheal extubation, conventional face mask oxygen therapy (at an oxygen flow rate of 5 L/min) is administered.

OTHER

Perioperative positive pressure ventilation

A PEEP of 10 cmH₂O is applied during general anesthesia induction; EIT-guided individualized PEEP is utilized during surgery; and following tracheal extubation, high-flow nasal cannula (HFNC) oxygen therapy (with an FiO₂ of 40%) is administered to maintain positive end-expiratory pressure.

Sponsors & Collaborators

  • Jun Zhang

    lead OTHER

Principal Investigators

  • Jun Zhang · Fudan University Shanghai Cancer Centre

Study Design

Allocation
RANDOMIZED
Purpose
PREVENTION
Masking
TRIPLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
90 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-03-20
Primary Completion
2026-09-20
Completion
2026-09-30

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07461285 on ClinicalTrials.gov