PRecision gerOMedicinE: Tailored Healthy agEing With Lifestyle, sUpplements and drugS (PROMETHEUS)

Summary

As the population ages, the growing prevalence of age-related diseases is creating substantial challenges for healthcare systems worldwide. Current therapeutic strategies often target individual diseases and decrease mortality without improving healthspan. The geroscience hypothesis suggests that targeting the ageing process itself could prevent, delay, or manage the severity of multiple age-related diseases concurrently, thereby improving overall healthspan and reducing healthcare burdens.

Emerging research highlights several interconnected hallmarks of aging, such as mitochondrial dysfunction, chronic inflammation, impaired autophagy, and immune dysregulation, as modifiable through targeted interventions. Precision geromedicine represents a paradigm shift in addressing these processes, combining baseline diagnostics with individualized treatment strategies that adapt over time based on patient response. This approach integrates lifestyle modifications, dietary supplements, and pharmacological agents to optimize physical, cognitive, and immune function across the lifespan .

Conditions

• Ageing

Interventions

OTHER

Sleep and dietary counseling

Sleep hygiene education and individualized dietary recommendations delivered throughout the intervention period.

OTHER

Supervised exercise and exergaming program

Supervised dual-task cognitive-physical training with an exergaming component conducted three times per week, 60 minutes per session.

BEHAVIORAL

Motivational interviewing

Structured motivational interviewing sessions aimed at improving adherence to lifestyle and supplementation interventions conducted two times throughout the study.

DIETARY_SUPPLEMENT

Whey protein

Daily whey protein supplementation (GOLD STANDARD 100% ISOLATE, Optimum Nutrition) provided using a standard 30 g scoop (\~25 g protein). Dosage based on body weight: 40-59 kg: 1 scoop/day 60-89 kg: 1.5 scoops/day ≥90 kg: 2 scoops/day

DIETARY_SUPPLEMENT

Creatine Monohydrate

Daily creatine supplementation (Micronized Creatine Monohydrate, Optimum Nutrition; 1.25 g per capsule). Dosage based on body weight: 40-59 kg: 4 capsules/day 60-89 kg: 6 capsules/day ≥90 kg: 8 capsules/day

DIETARY_SUPPLEMENT

Fucoidan

Daily fucoidan supplementation (SIRT6Activator®, DoNotAge.org) at a dose of 2.4 g/day.

DIETARY_SUPPLEMENT

Urolithin A

Participants below the 50th percentile for normative muscle mass receive urolithin A (StanYouth™ Urolithin A, Bonerge) at 250 mg/day.

DIETARY_SUPPLEMENT

Nicotinamide Mononucleotide (NMN)

Participants below the 50th percentile for normative VO₂peak receive NMN (AbinoNutra® NMN, Abinopharm, Inc.) at 300 mg/day.

DIETARY_SUPPLEMENT

Multivitamin

Participants below the 50th percentile for normative cognitive performance receive a gender-specific multivitamin (Centrum), 1 tablet daily.

DIETARY_SUPPLEMENT

Ergothioneine

At the midpoint of the intervention (1 month), participants may receive ergothioneine (Dr.Ergo® L-ergothioneine) at 25 mg three times per week based on individual response.

Sponsors & Collaborators

• Xprize Foundation

  collaborator UNKNOWN

• Abinopharm, Inc

  collaborator NETWORK

• DoNotAge.org

  collaborator INDUSTRY

• National University of Singapore

  lead OTHER

Principal Investigators

• Prof. Andrea Britta Maier, MD, PhD · National University of Singapore

Study Design

Allocation

NON_RANDOMIZED

Purpose

HEALTH_SERVICES_RESEARCH

Masking

NONE

Model

SEQUENTIAL

Eligibility

Min Age

50 Years

Max Age

80 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2025-09-29

Primary Completion

2026-02-23

Completion

2026-06-30

Countries

• Singapore

Study Locations