MedTrace Logo

Comprehensive Invasive Physiological Evaluation of Obstructive Coronary Artery Disease

NCT07449052 · Status: NOT_YET_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 450

Last updated 2026-05-01

No results posted yet for this study

Summary

The goal of this clinical trial is to test whether adding coronary function testing and starting targeted medical treatment for identified vasomotor disorders will also improve angina symptoms and quality of life in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention. The main question it aims to answer is:

Does performing coronary function testing in patients with obstructive coronary artery disease who undergo percutaneous coronary intervention lead to better relieve of angina symptoms and improvement in quality of life?

Researchers will compare this group undergoing coronary function testing with a control group who will solely undergo percutaneous coronary intervention.

Participants will:

* Undergo percutaneous coronary intervention and coronary function testing in the intervention arm
* Undergo percutaneous coronary intervention in the control arm

Conditions

  • Coronary Artery Disease (CAD)
  • Obstructive Coronary Artery Disease
  • Coronary Microvascular Dysfunction (CMD)
  • Vasospasm, Coronary
  • Stable Angina Pectoris

Interventions

DIAGNOSTIC_TEST

Coronary function testing

Coronary function testing to test for coronary microvascular dysfunction and coronary vasospasm

PROCEDURE

Percutaneous coronary intervention

Percutaneous coronary intervention performed according to local practice standards and guidelines

Sponsors & Collaborators

  • UMC Utrecht

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
DIAGNOSTIC
Masking
NONE
Model
PARALLEL

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-05-01
Primary Completion
2028-10-01
Completion
2029-03-01

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07449052 on ClinicalTrials.gov