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Volume Challenge Added to DSE in the Diagnosis of Severe LFLGAS

NCT03617406 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2022-05-17

No results posted yet for this study

Summary

The aim of this study is to test the diagnostic added value of Volume Challenge (VC) to low-dose dobutamine stress echocardiography (LDDSE) in patients with a low-flow, low-gradient aortic stenosis (LFLGAS). This study will assess if LDDSE plus VC allows to increase the proportion of patients in whom a true severe AS can be differentiated from a pseudo severe AS.

Conditions

  • Aortic Valve Stenosis

Interventions

DIAGNOSTIC_TEST

Volume Challenge

Addition volume challenge with passive leg raising method in LDDSE as well as administration of normal saline and dobutamine during TEE

Sponsors & Collaborators

  • Insel Gruppe AG, University Hospital Bern

    lead OTHER

Principal Investigators

  • Christian Seiler, MD · University Clinic for Cardiology, Inselspital, Bern

  • Stefano de Marchi, MD · University Clinic for Cardiology, Inselspital, Bern

Study Design

Allocation
NA
Purpose
DIAGNOSTIC
Masking
NONE
Model
SINGLE_GROUP

Eligibility

Min Age
18 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2018-05-31
Primary Completion
2020-12-31
Completion
2020-12-31

Countries

  • Switzerland

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT03617406 on ClinicalTrials.gov