Perception and Integration of Sensory Information in the Early Stages of Psychosis

Summary

The goal of this observational study is to investigate the early sensory system in clinical high risk (CHR), first episode psychosis (FEP) individuals and heathly controls. The main questions it aims to answer are:

* Can anomalies in visual and auditory sensory processing serve as early markers of psychosis risk?
* How are these sensory anomalies related to clinical symptom severity and emotional recognition deficits?

Researchers will compare CHR and PEP participants to healthy controls to see if sensory processing differences can help identify individuals at higher risk of developing psychosis.

Participants will:

* Complete behavioral tasks evaluating visual processing (contrast sensitivity, contour integration, facial emotion recognition, visual inference using Necker cubes) and auditory processing (tone-matching, auditory emotion recognition). A temporal perception component will also be assessed within the auditory and emotion recognition tasks, rather than as a separate task.
* Undergo electrophysiological assessments of retinal function using flash stimulation to record retinal potentials (a-wave, b-wave, phNR, oscillatory potentials).
* Provide demographic, clinical, and neuropsychological data during study visits.
* For CHR participants, attend follow-up visits up to 6 months post initial assessments to evaluate psychotic symptom progression.

Conditions

• Early Psychosis
• Schizophrenia Prodromal

Interventions

BEHAVIORAL

behavioral tasks

All participants will undergo behavioral assessments of visual and auditory processing, including contrast sensitivity, facial emotion recognition, visual inference using Necker cubes, tone-matching, and auditory emotion recognition.

DEVICE

Electroretinography

Participants will additionally undergo electrophysiological recordings of retinal function (a-wave, b-wave, phNR, oscillatory potentials) using flash stimulation.

DIAGNOSTIC_TEST

Comprehensive Assessment of At Risk Mental States (CAARMS)

All participants will be assessed using the CAARMS in order to evaluate their symptoms and classify them into either the CHR or FEP group

BEHAVIORAL

Neuropsychological tests

TAP attention and working memory test, fNART, VOSP, Verbal fluency test.

Sponsors & Collaborators

• Institut National de la Santé Et de la Recherche Médicale, France

  collaborator OTHER_GOV

• Centre Psychothérapique de Nancy

  lead OTHER

Principal Investigators

• Vincent LAPRÉVOTE, PU.PH · Centre Psychothérapique de Nancy

Study Design

Allocation

NA

Purpose

PREVENTION

Masking

NONE

Model

SINGLE_GROUP

Eligibility

Min Age

18 Years

Max Age

30 Years

Sex

ALL

Healthy Volunteers

Yes

Timeline & Regulatory

Start

2026-04-30

Primary Completion

2028-04-30

Completion

2028-11-30

Countries

• France

Study Locations