MedTrace Logo

Home-Based Quadriceps Isometric Exercise for Knee Osteoarthritis Pain

NCT07445568 · Status: COMPLETED · Phase: NA · Type: INTERVENTIONAL · Enrollment: 50

Last updated 2026-03-03

No results posted yet for this study

Summary

Knee osteoarthritis is a common cause of pain and reduced mobility in older adults. Many people have limited access to supervised rehabilitation programs, highlighting the need for simple and safe home-based treatment options.

This study evaluates whether a brief home-based quadriceps isometric exercise program can reduce knee pain in community-dwelling older adults. Participants perform short daily muscle contractions of the thigh muscles for 28 days. In addition, participants are assigned to receive one of four topical formulations (placebo, cannabidiol, arnica, or a combination of cannabidiol and arnica) to explore whether these products modify the exercise response.

The primary outcome is change in knee pain intensity measured using a visual analog scale. Secondary outcomes include adherence and safety. This pilot study aims to assess the feasibility, safety, and preliminary effectiveness of this low-cost and easily accessible strategy to inform future larger clinical trials.

Conditions

  • Older Adults (60 - 85 Years Old)
  • OA Knee

Interventions

DRUG

Placebo Topical Gel

Placebo topical formulation without active pharmacological ingredients, applied twice daily to the affected knee for 28 days.

DRUG

Cannabidiol (CBD) Topical Gel

Topical cannabidiol formulation applied twice daily to the affected knee for 28 days.

DRUG

Arnica montana Topical Gel

Topical Arnica montana formulation applied twice daily to the affected knee for 28 days.

BEHAVIORAL

Home-based Quadriceps Isometric Exercise

Daily home-based quadriceps isometric exercise protocol consisting of three sets of 10-second near-maximal voluntary contractions with rest intervals, performed for 28 days.

DRUG

CBD + Arnica Topical Gel

combined cannabidiol and arnica formulation applied twice daily

Sponsors & Collaborators

  • Universidad del Valle de México, Campus Cuernavaca

    lead OTHER

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
SINGLE
Model
FACTORIAL

Eligibility

Min Age
65 Years
Max Age
85 Years
Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2025-09-01
Primary Completion
2025-09-01
Completion
2025-11-01

Countries

  • Mexico

Study Locations

More Related Trials

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07445568 on ClinicalTrials.gov