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Burnout, Secondary Traumatic Stress and Inflammatory Biomarkers in ICU Healthcare Workers

NCT07437443 · Status: COMPLETED · Type: OBSERVATIONAL · Enrollment: 140

Last updated 2026-04-23

No results posted yet for this study

Summary

Healthcare professionals working in intensive care units (ICUs) are frequently exposed to high levels of psychological stress due to critically ill patients, frequent encounters with death, complex clinical decision-making, and prolonged working hours. This environment increases the risk of burnout and secondary traumatic stress, which may not only affect mental well-being but also have measurable physiological consequences.

Emerging evidence suggests that chronic psychological stress and burnout may influence immune function through activation of proinflammatory pathways. Elevated levels of inflammatory biomarkers such as C-reactive protein (CRP), interleukin-6 (IL-6), tumor necrosis factor-alpha (TNF-α), and neutrophil-to-lymphocyte ratio (NLR) have been associated with stress-related conditions. However, data examining the relationship between burnout, secondary traumatic stress, and inflammatory biomarkers in intensive care healthcare workers remain limited.

This cross-sectional observational study aims to investigate the association between burnout and secondary traumatic stress levels, assessed using validated psychometric instruments (Maslach Burnout Inventory and Professional Quality of Life Scale), and inflammatory biomarkers (CRP, IL-6, TNF-α, and NLR) in ICU healthcare workers. Blood samples will be obtained in conjunction with routine annual health screening, and additional serum samples will be collected for biomarker analysis. The study seeks to clarify the psychoneuroimmunological mechanisms underlying occupational stress in critical care settings.

Conditions

  • Burnout
  • Secondary Traumatic Stress
  • Occupational Stress
  • Inflammation
  • Critical Care Staff

Interventions

OTHER

Psychometric Assessment and Blood Sampling

Administration of validated burnout and secondary traumatic stress questionnaires and collection of blood samples for inflammatory biomarker analysis. No therapeutic or clinical intervention is performed.

Sponsors & Collaborators

  • Elazıg Fethi Sekin Sehir Hastanesi

    lead OTHER

Eligibility

Sex
ALL
Healthy Volunteers
No

Timeline & Regulatory

Start
2026-02-23
Primary Completion
2026-03-01
Completion
2026-03-10

Countries

  • Turkey (Türkiye)

Study Locations

More Related Trials

Entities

Diseases

Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07437443 on ClinicalTrials.gov