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Postoperative Pain After Single-Cone Root Canal Obturation Using Three Sealers

NCT07434141 · Status: ACTIVE_NOT_RECRUITING · Phase: NA · Type: INTERVENTIONAL · Enrollment: 75

Last updated 2026-02-25

No results posted yet for this study

Summary

The goal of this clinical trial is to compare post-treatment pain after root canal therapy in adults with irreversible pulpitis using different root canal sealers. The study will also evaluate the need for pain medication after treatment.

The main questions this study aims to answer are:

Does the type of root canal sealer affect the intensity of pain after treatment?

Does the type of sealer influence the number of analgesic tablets taken by participants?

How does pain change over time after treatment with different sealers?

Researchers will compare two bioceramic sealers (EndoSeal TCS and NeoSeal) with a resin-based sealer (AH Plus) to determine their effects on post-endodontic pain.

Participants will:

Receive root canal treatment using one of the study sealers

Report their pain intensity at specific time points after treatment

Record the number of analgesic tablets taken during the follow-up period

Conditions

  • Symptomatic Irreversible Pulpitis (SIP)
  • Symptomatic Irreversible Pulpitis With Apical Peridontitis

Interventions

PROCEDURE

Endoseal TCS

Bioceramic, premixed calcium silicate-based root canal sealer used for obturation with the single-cone technique during root canal treatment

PROCEDURE

Neosealer

Fast-setting calcium silicate-based bioceramic root canal sealer used for obturation with the single-cone technique during root canal treatment

PROCEDURE

AH Plus

Epoxy resin-based root canal sealer used for obturation with the single-cone technique during root canal treatment

Sponsors & Collaborators

  • Tehran University of Medical Sciences

    lead OTHER

Principal Investigators

  • Shole Ghabraei, Professor · Tehran university of medical science, school of dentistry

  • Hadi Assadian, Assistant Professor · Tehran university of medical science, school of dentistry

Study Design

Allocation
RANDOMIZED
Purpose
TREATMENT
Masking
DOUBLE
Model
PARALLEL

Eligibility

Min Age
18 Years
Max Age
60 Years
Sex
ALL
Healthy Volunteers
Yes

Timeline & Regulatory

Start
2025-06-08
Primary Completion
2026-04-30
Completion
2026-05-30

Countries

  • Iran

Study Locations

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Read the full study record

This page highlights key information. For complete eligibility criteria, study locations, investigator contacts, and the full protocol, visit the original record on ClinicalTrials.gov.

View NCT07434141 on ClinicalTrials.gov